
Tetrahedron Letters p. 341 - 342 (1987)
Update date:2022-07-29
Topics:
Garcia, Jordi
Vilarrasa, Jaume
Controlled reduction of N-alkyl-N-nitrosoamides to hydrazides followed by nitrosation and fragmentation affords azides in 80percent overall yields, under mild conditions.This simple idea is the basis of methods for the conversion of alkylamines and N-alkylamides to alkyl azides, of RNHCOR' into RNHCOR" or RN(COR''')2, and of lactames into ω-azido esters or ω-azido acids.
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