8-Aryl- and 8-cycloalkyl-1,3-dipropylxanthines: Further potent and selective antagonists for A1-adenosine receptors

DOI: 10.1021/jm00398a020

Source and publish data:

Journal of Medicinal Chemistry p. 613 - 617 (1988)

Update date:2022-08-04

Topics:

Authors:

Shamim Shamim

Ukena Ukena

Padgett Padgett

Hong Hong

Daly Daly

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Article abstract of DOI:10.1021/jm00398a020

A series of 1,3-dipropylxanthines were prepared with a variety of substituents at the 8-position. These included 8-aryl and 8-cycloalkyl groups. Polar carboxylate and carboxamide moieties were introduced as aryl substituents to increase water solubility.

Full text of DOI:10.1021/jm00398a020

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