Dihydropyrimidine Calcium Channel Blockers. 2. 3-Substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic Acid Esters as Potent Mimics of Dihydropyridines

DOI: 10.1021/jm00171a044

Source and publish data:

Journal of Medicinal Chemistry p. 2629 - 2635 (1990)

Update date:2022-07-31

Topics: Potent Dihydropyridines Mimics

Authors:

Atwal, Karnail S.

Rovnyak, George C.

Kimball, S. David

Floyd, David M.

Moreland, Suzanne

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00171a044

To enhance the intrinsic potency of dihydropyrimidine calcium channel blockers, we have modified the structure of previously described 2-heteroalkyl-1,4-dihydropyrimidines 2 to 3-substituted 1,4-dihydropyrimidines 3.Structure-activity studies using potass

Full text of DOI:10.1021/jm00171a044

Products guided by the article

Product name:<1(R)>-1,6-dihydro-2-methoxy-4-methyl-6(S)-(4-nitrophenyl)-1-<<(1-phenylethyl)amino>carbonyl>-5-pyrimidine carboxylic acid 1-methylethyl ester

Cas No:113116-81-7

R&D Labs maybe for 113116-81-7

Qingdao Kylin Trading Co., Ltd.

Contact:0086-532-68979884/58972912/68972263/65/88171519

Address:Room 2308,A building International Trade Center No.230 Changjiang Middle Road of Qingdao Economic Development Zone,Shandong,China.
HANGZHOU YUNUO CHEMICAL CO.,LTD

website:http://www.yunuochem.com

Contact:0571-83715115

Address:hangzhou
Xinji City Taida Sinopec Co., Ltd.

Contact:0086-311-85341278

Address:No.6, Nanhua Road,Xinji City Road,Hebei Province,China
NINGBO PANGS CHEM INT’L CO., LTD.

Contact:+86-0574-27666801

Address:Floor 21, Building 11, Xintiandi, No. 689, Shijiroad, Ningbo, Zhejiang, China
Sinonine Industry Co.,Ltd

Contact:86+21-56421993

Address:3F,BUILDING 10,NO.2889 JINKE ROAD, SHANGHAI.

Relevant to this article

A concise synthesis of siphonodictidine

Doi:10.1021/np0400860
(2004)
One-pot and sequential organic chemistry on an enzyme surface to tether a fluorescent probe at the proximity of the active site with restoring enzyme activity

Doi:10.1021/ja057926x
(2006)
Investigation of mechanism-based thrombin inhibitors: Implications of a highly conserved water molecule for the binding of coumarins within the S pocket

Doi:10.1016/j.bmcl.2005.12.070
(2006)
Cycloaddition chemistry of 1,3-thiazolium-4-olate systems. Reaction with nitroalkenes and interpretation of results using PM3 calculations

Doi:10.1021/jo952275g
(1996)
A NEW ONE-POT METHOD FOR α,α-DIALLYLATION OF KETONES BASED ON THE PALLADIUM-CATALYZED REACTION OF ALLYLIC CARBONATES AND ALLYL β-KETO CARBOXYLATES UNDER NEUTRAL CONDITIONS

Doi:10.1016/S0040-4039(00)94297-7
(1983)
Preparation of Fluorine-Containing Phenylacetylenes by the Method of Introduction of the Ethynyl Group Using 1,1-Dichloro-2,2-difluroethene

Doi:10.1246/bcsj.61.1625
(1988)

Article Doi