Dihydropyrimidine Calcium Channel Blockers. 2. 3-Substituted-4-aryl-1,4-dihydro-6-methyl-5-pyrimidinecarboxylic Acid Esters as Potent Mimics of Dihydropyridines

DOI: 10.1021/jm00171a044

Source and publish data:

Journal of Medicinal Chemistry p. 2629 - 2635 (1990)

Update date:2022-07-31

Topics: Potent Dihydropyridines Mimics

Authors:

Atwal, Karnail S.

Rovnyak, George C.

Kimball, S. David

Floyd, David M.

Moreland, Suzanne

et al. et al.

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Article abstract of DOI:10.1021/jm00171a044

To enhance the intrinsic potency of dihydropyrimidine calcium channel blockers, we have modified the structure of previously described 2-heteroalkyl-1,4-dihydropyrimidines 2 to 3-substituted 1,4-dihydropyrimidines 3.Structure-activity studies using potass

Full text of DOI:10.1021/jm00171a044

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