A RALEY APPROACH TO (+)-PLEUROMUTILIN. III. DIRECT DEGRADATION OF THE NATURAL PRODUCT TO THE KEY DIKETONE INTERMEDIATE AND ITS CHEMOSPECIFIC FUNCTIONALIZATION

DOI: 10.1016/S0040-4039(00)98565-4

Source and publish data:

Tetrahedron Letters p. 1611 - 1614 (1985)

Update date:2022-08-05

Topics:

Authors:

Paquette, Leo A.

Wiedeman, Paul E.

Bulman-Page, Philip C.

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Article abstract of DOI:10.1016/S0040-4039(00)98565-4

Pleuromutilin or tiamulin can be degraded to the important bicyclic relay compound (-)-1 in only four steps.Various methods for achieving chemoselective functionalization of 1 are set in focus.

Full text of DOI:10.1016/S0040-4039(00)98565-4

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