SYNTHESIS OF 4-SUBSTITUTED 1-METHYL(BENZYL)-2,5-DIMETHYL-4-R-AMINOPIPERIDINES

Article abstract of DOI:10.1007/BF00475651

Schiff base derivatives of 1-methyl(benzyl)-2,5-dimethylpiperidin-4-ones with phenyl, α-pyridyl, benzyl, and β-hydroxyethyl substituents attached to the imine nitrogen atom react with organometallic compounds to give analogously substituted piperidine bases with methyl, allyl, phenyl, and benzyl substituents in the the 4-position.Pure individual geometric isomers of these newly synthetised compound have been isolated and their structures determined.