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Experimental Section
General Procedure for the Cross-Coupling of Aryl
Halides with Arenes
An oven-dried Schlenk tube equipped with a magnetic stir
bar was charged with aryl halides (0.5 mmol, if solid), L3
(41 mg, 0.12 mmol) and KO-t-Bu (168 mg, 1.5 mmol) under
a nitrogen atmosphere at room temperature. Anhydrous
benzene/arene (2.25 mL) and aryl halides (0.5 mmol, if
liquid) were then added using a syringe. The tube was then
sealed and the resulting mixture was stirred at the specified
temperature until complete consumption of starting material
as monitored by TLC. After cooling to room temperature,
the reaction mixture was quenched and extracted with ethyl
acetate (10 mLꢁ3). The organic layers were combined,
dried over Mg2SO4 and concentrated under reduced pres-
sure. The crude products were purified through flash
column chromatography on 230–400 mesh silica gel using
hexane or hexane/ethyl acetate as eluent with a suitable
ratio according to the TLC experiments. The regioisomeric
distributions of isomers were determined by GC and con-
firmed by 1H NMR spectroscopy.
Acknowledgements
We thank the National Science Council of Taiwan for sup-
porting this work.
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