Diastereoselective synthesis of dimethyl (4R*,4a′R*, 7a′R*)-1-Aryl-6′-benzoyl- 4a′-methyl-5-oxo-1,4′, 4a′,5,5′,6′-hexahydrospiro[pyrazole-4,7′-pyrrolo[3,4-c] pyridazine]-3′,7a′(1′H)-dicarboxylates

Article abstract of DOI:10.1055/s-0028-1083291

Methyl (Z)-2-(benzoylamino)-3-(dimethylamino)prope- noate (1) reacted with trimethylenemethane (2) to produce methyl (Z)-2-[benzoyl(2-methylallyl)amino]-3- (dimethylamino)propeno- ate (3), which was then converted into pyrazole derivatives 11a-h by a cons