A NEW STRATEGY FOR DINUCLEOTIDE SYNTHESIS VIA PHOSPHITE ROUTE INVOLVING PHOSPHOROCHLORIDATES AS INTERMEDIATES

DOI: 10.1016/S0040-4039(00)95534-5

Source and publish data:

Tetrahedron Letters p. 3559 - 3560 (1987)

Update date:2022-08-03

Topics:

Authors:

Dabkowski, Wojciech

Cramer, Friedrich

Michalski, Jan

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Article abstract of DOI:10.1016/S0040-4039(00)95534-5

Readily available nucleoside trimethylsilyl phosphites and analoguous compounds are transformed in high yield into the corresponding phosphorochloridates by reaction with sulfuryl chloride.These compounds are employed as efficient reagents for internucleotide linkage formation.

Full text of DOI:10.1016/S0040-4039(00)95534-5

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Product name:Adenosine, N-benzoyl-2'-deoxy-5'-O-[(1,1-dimethylethyl)dimethylsilyl]-, 3'-(2,2,2-trifluoroethyl trimethylsilyl phosphite)

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