A NEW SYNTHESIS OF PHOSPHOROFLUORIDATES OF BIOLOGICAL INTEREST. THE REACTION OF PHOSPHOROAZOLIDES WITH BENZOYL FLUORIDE

Article abstract of DOI:10.1016/S0040-4039(00)95535-7

Phosphoroazolides, including nucleoside derivatives, can be converted smoothly into the corresponding phosphorofluoridates by reaction with benzoyl fluoride.From these compounds oligonucleotides containing <*>P-F instead of <*>P-OH can be prepared.