Orally Potent Human Renin Inhibitors Derived from Angiotensinogen Transition State: Design, Synthesis, and Mode of Interaction

DOI: 10.1021/jm00172a005

Source and publish data:

Journal of Medicinal Chemistry p. 2707 - 2714 (1990)

Update date:2022-08-04

Topics:

Authors:

Iizuka, Kinji

Kamijo, Tetsuhide

Herada, Hiromu

Akahane, Kenji

Kubota, Tetsuhiro

et al. et al.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00172a005

A three-dimensional structure of the complex of human renin and the scissile site P₄ Pro to P₁' Val of angiotensinogen was deduced in order to design potent human renin inhibitors rationally.On the basis of this structure, an orally

Full text of DOI:10.1021/jm00172a005

Products guided by the article

Product name:isopropyl (2S,3S)-3-amino-4-cyclohexyl-2-hydroxybutyrate hydrochloride

Cas No:115131-72-1

R&D Labs maybe for 115131-72-1

Shanghai Bocimed Pharmaceutical Co., Ltd.

website:http://www.bocimed.com

Contact:+86-21-68861632

Address:Building 1, Lane 647, Songtao Road, Zhangjiang High-Tech Park, Shanghai
zhenjiang runjing high purity chemical co ltd

Contact:+86-511-83361155

Address:No.8.haixi road,international chemical park
Jiangxi Lanqi Fine Chemical S&T Co., Ltd.

Contact:+86-21-64891143

Address:XinJiShan Industrial Area, Zhangshu City, JiangXi Province, China
Sdow

website:http://www.sdowchem.com

Contact:86-135-2193 7483

Address:8-106 taiyue building
Nanjing Norris Pharm Technology Co., Ltd.

Contact:+86-13901585132

Address:2 Qiande Road, Jiangning sciencepark Hi-Tech Zone, Nanjing, P.R.China

Relevant to this article

Photocatalytic Vicinal Aminopyridylation of Methyl Ketones by a Double Umpolung Strategy

Doi:10.1002/anie.202008435
(2020)
Stereocontrolled, total synthesis of α-D-GalA-<(1->4)-α-D-GalA>8-(1->4)-β-D-GalA-1->OPr, a synthetic model for phytoalexin elicitor-active oligogalacturonic acids

Doi:10.1016/0008-6215(87)80292-6
(1987)
Glycosyl sulfonium ions as storable intermediates for glycosylations

Doi:10.1021/ol200242u
(2011)
Reaction of carbohydrates with Vilsmeier reagent: A tandem selective chloro O-formylation of sugars

Doi:10.1039/b900026g
(2009)
A stereo flexible total synthesis of Karalicin, an antiviral agent

Doi:10.1080/00397919708005908
(1997)
Design, synthesis and biological evaluation of imine resveratrol derivatives as multi-targeted agents against Alzheimer's disease

Doi:10.1016/j.ejmech.2013.10.068
(2014)

Article Doi