Orally Potent Human Renin Inhibitors Derived from Angiotensinogen Transition State: Design, Synthesis, and Mode of Interaction

Article abstract of DOI:10.1021/jm00172a005

A three-dimensional structure of the complex of human renin and the scissile site P₄ Pro to P₁' Val of angiotensinogen was deduced in order to design potent human renin inhibitors rationally.On the basis of this structure, an orally