Orally Potent Human Renin Inhibitors Derived from Angiotensinogen Transition State: Design, Synthesis, and Mode of Interaction

DOI: 10.1021/jm00172a005

Source and publish data:

Journal of Medicinal Chemistry p. 2707 - 2714 (1990)

Update date:2022-08-04

Topics:

Authors:

Iizuka, Kinji

Kamijo, Tetsuhide

Herada, Hiromu

Akahane, Kenji

Kubota, Tetsuhiro

et al. et al.

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Article abstract of DOI:10.1021/jm00172a005

A three-dimensional structure of the complex of human renin and the scissile site P₄ Pro to P₁' Val of angiotensinogen was deduced in order to design potent human renin inhibitors rationally.On the basis of this structure, an orally

Full text of DOI:10.1021/jm00172a005

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