Synthesis, conformation, and immunosuppressive activitiy of a conformationally restricted cyclosporine lactam analogue

DOI: 10.1021/jm00117a022

Source and publish data:

Journal of Medicinal Chemistry p. 1805 - 1815 (1988)

Update date:2022-08-03

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Authors:

Aebi Aebi

Guillaume

Dunlap Dunlap

Rich Rich

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Article abstract of DOI:10.1021/jm00117a022

Cyclosporine A (CsA, 1), an immunosuppressive cyclic undecapeptide, in apolar solvents adopts a II' β-turn at the Sar³-MeLeu⁴ residues. [D-Proline³]Cs has been reported to be a nonimmunosuppressive analogue in which the II

Full text of DOI:10.1021/jm00117a022

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