Synthesis, conformation, and immunosuppressive activitiy of a conformationally restricted cyclosporine lactam analogue

Article abstract of DOI:10.1021/jm00117a022

Cyclosporine A (CsA, 1), an immunosuppressive cyclic undecapeptide, in apolar solvents adopts a II' β-turn at the Sar³-MeLeu⁴ residues. [D-Proline³]Cs has been reported to be a nonimmunosuppressive analogue in which the II