Renin inhibitors containing hydrophilic groups. Tetrapeptides with enhanced aqueous solubility and nanomolar potency

DOI: 10.1021/jm00118a009

Source and publish data:

Journal of Medicinal Chemistry p. 1918 - 1923 (1988)

Update date:2022-08-05

Topics:

Authors:

Bock Bock

DiPardo DiPardo

Evans Evans

Freidinger

Rittle Rittle

Payne Payne

Boger Boger

Whitter Whitter

LaMont LaMont

Ulm Ulm

Blaine Blaine

Schorn Schorn

Veber Veber

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Article abstract of DOI:10.1021/jm00118a009

Nineteen tetrapeptides containing statine (Sta) and 4-amino-5-cyclohexyl-3-hydroxypentanoic acid (ACHPA) were prepared. Solubility measurements of these compounds were carried out in H₂O and in pH 7.4 phosphate buffer solution, and their partit

Full text of DOI:10.1021/jm00118a009

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