Renin inhibitors containing hydrophilic groups. Tetrapeptides with enhanced aqueous solubility and nanomolar potency

DOI: 10.1021/jm00118a009

Source and publish data:

Journal of Medicinal Chemistry p. 1918 - 1923 (1988)

Update date:2022-08-05

Topics:

Authors:

Bock Bock

DiPardo DiPardo

Evans Evans

Freidinger

Rittle Rittle

Payne Payne

Boger Boger

Whitter Whitter

LaMont LaMont

Ulm Ulm

Blaine Blaine

Schorn Schorn

Veber Veber

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00118a009

Nineteen tetrapeptides containing statine (Sta) and 4-amino-5-cyclohexyl-3-hydroxypentanoic acid (ACHPA) were prepared. Solubility measurements of these compounds were carried out in H₂O and in pH 7.4 phosphate buffer solution, and their partit

Full text of DOI:10.1021/jm00118a009

Products guided by the article

Product name:2-Amino-4-((S)-2-{(3S,4S)-4-[(S)-2-((S)-2-tert-butoxycarbonylamino-3-phenyl-propionylamino)-3-(3H-imidazol-4-yl)-propionylamino]-3-hydroxy-6-methyl-heptanoylamino}-4-methyl-pentanoylamino)-butyric acid

Cas No:115511-05-2

R&D Labs maybe for 115511-05-2

Changzhou Kingyo Chemical Corporation Ltd.

website:http://www.kingyochem.com

Contact:+86-519-85105717

Address:19# Wuqing North Road, Changzhou , Jiangsu, China
Jiangsu King Road New Materials Co., Ltd.

website:http://www.jskingroad.com

Contact:0519-85720726 0519-85720721 13584535752

Address:No.1,Weihua Road,Xinbei District,Changzhou City,Jiangsu Province
SHIJIAZHUANG CHENSHI IMPORT AND EXPORT CO.,LTD

Contact:+86-311-89871056

Address:RM2017 BUILDING CTIANSHAN GALAXY PLAZA,NO168 CHANGJIANG ROAD,GAOXIN DISTRICT,SHIJIAZHUANG CITY, HEBEI,CHINA
Dragon Chemical Co., Ltd.

Contact:0571-

Address:zhejing
Zhuhai Jiacheng Biological Technology Co., Ltd

Contact:0756-8800233

Address:room 222, Lianhua road , Gongbei ,Zhuhai, Guangdong ,China

Relevant to this article

Synthesis of (±)-fredericamycin A

Doi:10.1021/ja00227a030
(1988)
t-butyl hydroperoxide oxidative dealkylation of hydroquinone ethers to 1,4-quinones

Doi:10.1080/00397910600634175
(2006)
Alkyne [3 + 2] cycloadditions of iodosydnones toward functionalized 1,3,5-trisubstituted pyrazoles

Doi:10.1021/jo902514v
(2010)
Electrochemical Activation of Diverse Conventional Photoredox Catalysts Induces Potent Photoreductant Activity**

Doi:10.1002/anie.202107169
(2021)
Conventional and microwave-assisted synthesis of benzimidazole derivatives and their in vitro inhibition of human cyclooxygenase

Doi:10.1002/jhet.1058
(2012)
Anti-trypanosomatid benzofuroxans and deoxygenated analogues: Synthesis using polymer-supported triphenylphosphine, biological evaluation and mechanism of action studies

Doi:10.1016/j.ejmech.2009.09.009
(2009)

Article Doi