H. Duan et al. / Bioorg. Med. Chem. Lett. 19 (2009) 2777–2779
2779
more analogs will be prepared to optimize the PDE5 inhibitory
activity and selectivity further.
O2S
N
N
O2S
N
N
R1
O
R1
O
N
O
N
i
NH
O
Acknowledgments
NH
O
O
OH
O
The authors gratefully acknowledge the financial support of the
National 863 Program of China (Grant No. 2007AA02Z145) and
Shanghai Science and Technology Development Funds (Grant No.
08JC1422400).
11a-j
12a-j
Scheme 3. Reagents and conditions: (i) BBr3, CH2Cl2, À10 °C, 4 h.
Table 2
Supplementary data
In vivo results for 11b and sildenafil
Compd
ICP/BPa
Supplementary data associated with this article can be found, in
Vehicle
Sildenafil
11b
30.04 8.26
55.89 5.59b
50.44 5.36b
References and notes
Comparison of the erectile function in male rats treated with 11b and Sildenafil
17
(n = 5). Assays carried out as described in Ref.
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