Effects of Addition of a 2-Methyl Group to Ethyl Nipecotates (β-Meperidines) on Receptor Affinities and Opiate Agonist/Antagonist Activities

DOI: 10.1021/jm00118a028

Source and publish data:

Journal of Medicinal Chemistry p. 2015 - 2021 (1988)

Update date:2022-08-04

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Authors:

Lawson, John A.

Cheng, Alice

DeGraw, Joseph

Frenking, Gernot

Uyeno, Edward

et al. et al.

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Article abstract of DOI:10.1021/jm00118a028

A series of 2-methyl-3-carbethoxy-3-(m-hydroxyphenyl)piperidine opiates (13a-d) with N-substituent variations have been synthesized, and their receptor affinities and in vivo agonist and antagonist activities and energy-conformational profiles have been d

Full text of DOI:10.1021/jm00118a028

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