The Peptide Way to Macrocyclic Bifunctional Chelating Agents: Synthesis of 2-(p-Nitrobenzyl)-1,4,7,10-tetraazacyclododecane-N,N',N'',N'''-tetraacetic Acid and Study of Its Yttrium(III) Complex

Article abstract of DOI:10.1021/ja00226a063

It was shown that the 12-membered polyazamacrocycle is the favored target for binding trivalent yttrium.We have developed a new synthetic route to these macrocycles via peptide synthesis and intramolecular tosylamide ring closure.