Stereoselective Synthesis of the C-8 to C-15 Moiety of Erythronolide A

DOI: 10.1021/jo00255a013

Source and publish data:

Journal of Organic Chemistry p. 4730 - 4735 (1988)

Update date:2022-08-05

Topics: Synthesis Chiral Catalyst Stereoselective High-performance liquid chromatography (HPLC) Diastereomers Reaction Substrate erythronolide A

Authors:

Hoagland, Steven

Morita, Yasushi

Bai, Dong Lu

Maerki, Hans-Peter

Kees, Kenneth

et al. et al.

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Article abstract of DOI:10.1021/jo00255a013

Enantiomerically pure ketone 2, corresponding to the C-8, C-15 segment of erythronolide A, has been prepared by a 12-step route with crotyl alcohol as starting material in 5-6percentoveral yield.The synthesis starts with trisylhydrazone 4, which is conver

Full text of DOI:10.1021/jo00255a013

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