Preparation of Derivatives of (R)-1,2,4-Butanetriol from L-Ascorbic Acid

Article abstract of DOI:10.1055/s-1988-27521

Methyl 3,4-O-isopropylidene L-threonate (3), obtained from L-ascorbic acid, was converted to its O-phenyl thiocarbonate 4.Deoxygenation of 4 with tri-n-butyltin hydride gave the protected 3,4-dihydroxybutanoate 5, which was converted to the (R)-1,2,4-butanetriol derivatives 6 and 7.