α-Amino Acids as Chiral Educts for Asymmetric Products. Alkylation of N-Phenylfluorenyl α-Amino Ketones. Synthesis of Optically Pure α-Alkyl Carboxylic Acids

Article abstract of DOI:10.1021/ja00230a027

Regioselective enolization and alkylation of N-(9-phenylfluoren-9-yl)amino ketones provides diastereomeric mixtures of α'-alkyl branched α-amino ketones.Separation of the diastereomers provides >99 percent enantiomerically pure α'-alkyl branched α-amino k