Synthesis and Cardiac Electrophysiological Activity of Aryl-Substituted Derivatives of the Class III Antiarrhythmic Agent Sematilide. Potential Class I/III Agents

Article abstract of DOI:10.1021/jm00164a025

Twelve novel derivatives of the selective class III antiarrhythmic agent sematilide were prepared in an attempt to incorporate both class I and class III electrophysiological properties into a single molecule.Electrophysiological activity was determined b