Synthesis and Antiallergy Activity of 4-(Diarylhydroxymethyl)-1-piperidines and Structurally Related Compounds

DOI: 10.1021/jm00121a022

Source and publish data:

Journal of Medicinal Chemistry p. 105 - 118 (1989)

Update date:2022-08-03

Topics:

Authors:

Walsh, David A.

Franzyshen, Stephen K.

Yanni, John M.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00121a022

A series of 4-(diarylhydroxymethyl)-1-<3-(aryloxy)propyl>piperidines was synthesized and evaluated for antiallergy activity.Several analogues had potent activity in the passive foot anaphylaxis (PFA) assay, an IgE-mediated model useful in the detection of compounds possessing antiallergic activity.In particular 1-<4-<3-<4--1-piperidinyl>propoxy>-3-methoxyphenyl>ethanone (1, AHR-5333) was more potent than oxatomide and terfenadine in this assay.

Full text of DOI:10.1021/jm00121a022

Products guided by the article

Product name:1-<4-(4-chlorobutoxy)-3-methoxyphenyl>ethanone

Cas No:117022-40-9

R&D Labs maybe for 117022-40-9

Liaoning Yufeng Chemical Co.,Ltd.

Contact:86-0419-3418888

Address:The metallurgical industrial zone,shoushan town, Liaoyang, Liaoning, China
Zhejiang Haizhou Pharmaceutical Co., Ltd.

website:https://www.haizhoupharma.com/

Contact:+86-576-88221016

Address:No. 19, Donghai 5th Avenue, Yanhai Industrial Zone, Linhai, Zhejiang, China
Dongying J&M Chemical Co., Ltd,

Contact:546-8551108

Address:Room 1219, Zisheng Mansion, Zibo Road, Dongying, Shandong, China
Wuhan Kemi-Works Chemical Co., Ltd

website:http://www.kemiworks.com

Contact:86-27-85736489

Address:Rm. 1503, No. 164, Jianghan North Rd., Wuhan, 430022 China
Zhenjiang Haitong Chemical Industry Co., Ltd.

Contact:+86 (511) 8448-0369

Address:Baoyan Town, Dantu District, Zhenjiang City, Jiangsu, China

Relevant to this article

Hydrophilically augmented glycosyl carborane derivatives for incorporation in antibody conjugation reagents

Doi:10.1021/om00102a015
(1988)
Metallacycle formation through the linking of an alkyne with phosphido and acetyl groups at an iron centre: X-ray structure of (Cp = η⁵-C5H5)

Doi:10.1016/0022-328X(93)80360-N
(1993)
Synthesis of C-2 methylene O- and C-glycosides and sugar derived α-methylene-δ-valerolactones from C-2-acetoxymethyl glycals

Doi:10.1016/S0040-4020(00)00775-4
(2000)
New chiral diphosphites derived from substituted 9,10-dihydroanthracene. Applications in asymmetric catalytic processes

Doi:10.1016/j.tetasy.2009.02.052
(2009)
Improved synthesis of 2,3:4,6-di-O-isopropylidene-D-glucopyranose and -D-galactopyranose

Doi:10.1016/S0008-6215(99)00150-0
(1999)
1,7-electrocyclization reactions of 2-Aza-4,5-benzoheptatrienyl- and 4-Aza-6,7-benzononatetraenyllithium compounds: Synthesis of novel 2-benzazepines and (benzocyclooctenyl) amines

Doi:10.1002/ejoc.200801295
(2009)

Article Doi