Synthesis and Antiallergy Activity of 4-(Diarylhydroxymethyl)-1-piperidines and Structurally Related Compounds

DOI: 10.1021/jm00121a022

Source and publish data:

Journal of Medicinal Chemistry p. 105 - 118 (1989)

Update date:2022-08-03

Topics:

Authors:

Walsh, David A.

Franzyshen, Stephen K.

Yanni, John M.

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Article abstract of DOI:10.1021/jm00121a022

A series of 4-(diarylhydroxymethyl)-1-<3-(aryloxy)propyl>piperidines was synthesized and evaluated for antiallergy activity.Several analogues had potent activity in the passive foot anaphylaxis (PFA) assay, an IgE-mediated model useful in the detection of compounds possessing antiallergic activity.In particular 1-<4-<3-<4--1-piperidinyl>propoxy>-3-methoxyphenyl>ethanone (1, AHR-5333) was more potent than oxatomide and terfenadine in this assay.

Full text of DOI:10.1021/jm00121a022

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