A practical synthesis of ethyl 1,2,4-triazole-3-carboxylate and its use in the formation of chiral 1',2'-seco-nucleosides of ribavirin

DOI: 10.1002/jhet.5570250253

Source and publish data:

Journal of Heterocyclic Chemistry p. 651 - 654 (1988)

Update date:2022-08-03

Topics: Synthesis Chiral Ribavirin Experimental

Authors:

Vemishetti

Leiby Leiby

Abushanab

Panzica Panzica

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Article abstract of DOI:10.1002/jhet.5570250253

A practical and efficient synthesis of ethyl 1,2,4-triazole-3-carboxylate (6a, R'' = H) from ethyl carboethoxyformimidate hydrochloride is described. Alkylation of this heterocycle with the chloromethyl ethers of 1,3-O-dibenzylbutane-1,2R,3S-triol and 1,3

Full text of DOI:10.1002/jhet.5570250253

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Product name:1-<(1,3S-dibenzyloxy-2R-butoxy)methyl>-1,2,4-triazole-3-carboxamide

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