Diethyl bromodifluoromethylphosphonate: a highly efficient and environmentally benign difluorocarbene precursor

DOI: 10.1016/j.tet.2009.04.082

Source and publish data:

Tetrahedron p. 5278 - 5283 (2009)

Update date:2022-09-26

Topics: Precursor Intermediate Difluorocarbene Environmentally benign

Authors:

Zafrani, Yossi

Sod-Moriah, Gali

Segall, Yoffi

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Article abstract of DOI:10.1016/j.tet.2009.04.082

A convenient method for the difluoromethylation of phenols and thiophenols, using diethyl bromodifluoromethylphosphonate (1) as a difluorocarbene precursor, is described. This commercially available phosphonate was found to undergo an extremely facile P-C

Full text of DOI:10.1016/j.tet.2009.04.082

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