Synthesis and biological evaluation of a monocyclic, fully functional analogue of compactin

DOI: 10.1021/jm00121a036

Source and publish data:

Journal of Medicinal Chemistry p. 197 - 202 (1989)

Update date:2022-07-30

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Authors:

Heathcock

Davis Davis

Hadley Hadley

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Article abstract of DOI:10.1021/jm00121a036

Compound 8, a monocyclic analogue of compactin, has been prepared and its efficacy as an inhibitor of 3-hydroxy-3-methylglutarylcoenzyme A reductase (HMGR) evaluated. The synthesis (Schemes I and II) requires seven steps starting with di-(-)-menthyl fumar

Full text of DOI:10.1021/jm00121a036

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