Journal of Medicinal Chemistry p. 197 - 202 (1989)
Update date:2022-07-30
Topics:
Heathcock
Davis
Hadley
Compound 8, a monocyclic analogue of compactin, has been prepared and its efficacy as an inhibitor of 3-hydroxy-3-methylglutarylcoenzyme A reductase (HMGR) evaluated. The synthesis (Schemes I and II) requires seven steps starting with di-(-)-menthyl fumar
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