Synthesis and biological evaluation of a monocyclic, fully functional analogue of compactin

DOI: 10.1021/jm00121a036

Source and publish data:

Journal of Medicinal Chemistry p. 197 - 202 (1989)

Update date:2022-07-30

Topics:

Authors:

Heathcock

Davis Davis

Hadley Hadley

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00121a036

Compound 8, a monocyclic analogue of compactin, has been prepared and its efficacy as an inhibitor of 3-hydroxy-3-methylglutarylcoenzyme A reductase (HMGR) evaluated. The synthesis (Schemes I and II) requires seven steps starting with di-(-)-menthyl fumar

Full text of DOI:10.1021/jm00121a036

Products guided by the article

Product name:(1S,2S,2'S)-1-(hydroxymethyl)-2-<<(2'-methyl-1-oxobutyl)oxy>methyl>cyclohex-4-ene

Cas No:117678-57-6

R&D Labs maybe for 117678-57-6

Tai zhou world Pharm & Chem Co., Ltd

Contact:+86-576-85301198

Address:Rome 1001,wangjiang plaza,unti 2,jinshan east Road linhai,zhejiang,china
Tianjin Pharmacn Medical Technology Co.,Ltd.

Contact:86-22-60122566ext.866(English),23359620

Address:Green Industrial Base, 6 Haitaifazhan Sixth Rd., Huayuan Industrial Area, Tianjin, 300384, China
Shenzhen Sunrising Industry Co., ltd.

Contact:+86 755 86571158 / 86571159 / 86571160

Address:2108 ZHENYE INT. BUSINESS CENTER,NO.3101-90 QIANHAI RD, NANSHAN,SHENZHEN, CHINA
Shantou Baokang Pharmaceutical Co., Ltd.

Contact:+86-754-88873487

Address:5/F B Block Huangshan Bldg Huangshan Rd Shantou
Jiaxing Barton Chemicals

website:http://www.chinabarton.com

Contact:+86-573-82719618

Address:No. 162 Fumin Road, Honghe Town,

Relevant to this article

A Theoretical and Experimental Investigation of Vicinal Tricarbonyl Systems and Their Hydrates

Doi:10.1021/jo00062a029
(1993)
Daphniphyllum Alkaloids. 11. Biomimetic Total Synthesis of Methyl Homosecodaphniphyllate. Development of the Tetracyclization Reaction

Doi:10.1021/jo00035a008
(1992)
Evaluation of 6-APA as a new organocatalyst for a direct cross-aldol reaction

Doi:10.1002/ejoc.200900181
(2009)
PROTONATED FORMS OF N-VINYLPYRROLES

Doi:10.1007/BF00475322
(1988)
Hexadecapropyloxy-substituted diphthalocyanine complexes of rare-earth elements: Synthesis, spectroscopic and electrochemical studies

Doi:10.1023/A:1026036100317
(2003)
Rapid chemoenzymatic route to glutamate transporter inhibitor l-TFB-TBOA and related amino acids

Doi:10.1039/c7ob00305f
(2017)

Article Doi