Total synthesis of natural (-)combretastatin D-1

DOI: 10.1016/0040-4039(95)01987-S

Source and publish data:

Tetrahedron Letters p. 9369 - 9372 (1995)

Update date:2022-08-04

Topics:

Authors:

Couladouros, Elias A.

Soufli, Loanna C.

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Article abstract of DOI:10.1016/0040-4039(95)01987-S

Combretastatin D-1, (2), was synthesized via a 12 step sequence. Sharpless asymmetric dihydroxylation was used in order to introduce the appropriate asymmetry. Regiospecific cyclodehydration of the diol 3 gave the title compound in 96% ee.

Full text of DOI:10.1016/0040-4039(95)01987-S

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