Tetrahedron Letters p. 9369 - 9372 (1995)
Update date:2022-08-04
Topics:
Couladouros, Elias A.
Soufli, Loanna C.
Combretastatin D-1, (2), was synthesized via a 12 step sequence. Sharpless asymmetric dihydroxylation was used in order to introduce the appropriate asymmetry. Regiospecific cyclodehydration of the diol 3 gave the title compound in 96% ee.
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