A Synthetic Approach to Rocaglamide via Reductive Cyclization of δ-Keto Nitriles

DOI: 10.1021/jo00262a022

Source and publish data:

Journal of Organic Chemistry p. 77 - 83 (1989)

Update date:2022-07-30

Topics:

Authors:

Kraus, George A.

Sy, James O.

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Article abstract of DOI:10.1021/jo00262a022

The anticancer agent rocaglamide contains a novel bicyclo<3.3.0>octanol structure.The approach to this molecule involved the preparation of a hydroxy ketone intermediate via a samarium-mediated cyclization.This ketone was then converted into an excellent

Full text of DOI:10.1021/jo00262a022

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