New Methods and Reagents in Organic Synthesis; 73. Trimethylsilyldiazomethane: A Convenient Reagent for the Conversion of Aliphatic Aldehydes to the Homologous Methyl Ketones

DOI: 10.1055/s-1988-27522

Source and publish data:

Synthesis p. 228 - 229 (1988)

Update date:2022-07-30

Topics:

Authors:

Aoyama, Toyohiko

Shioiri, Takayuki

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Article abstract of DOI:10.1055/s-1988-27522

Trimethylsilyldiazomethane reacts smoothly with aliphatic aldehydes in the presence of magnesium bromide (1.5 eqiv) to give homologous methyl ketones after direct treatment with 10percent hydrochloric acid/methanol (1:1).

Full text of DOI:10.1055/s-1988-27522

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