Journal of Organic Chemistry p. 411 - 414 (1989)
Update date:2022-07-29
Topics:
Kurth, Mark J.
Bloom, Steven H.
The iodolactamization of a series of γ,δ-unsaturated oxazolines has been studied (i -> iii).The data presented establish that the resulting hydroxy iodo lactams are produced in high yield and regioselectively.No asymmetric induction is observed with substituents on the oxazoline ring or at the homoallylic position; however, moderate to high 1,2-asymmetric induction can be obtained with a substituent at the allylic position.Most importantly, these results establish that the iodolactamization of γ,δ-unsaturated oxazolines is a kinetically controlled process proceeding via the intermediacy of ii.
View MoreLyrin Industrial Corporation Limited
Contact:86-731-82571800
Address:Rm 2408,Asia Economy International Building,Shaoshan Road South,Yuhua District,Changsha,Hunan,China
Contact:+86-0592 5353131
Address:No.56 Guani Road Software Park 2,Siming District
Hangzhou Pharma & Chem Co.,Ltd.
Contact:+86-571-87040515
Address:No,139Qingchun Rd
Huludao Tianqi Shengye Chemical Co.,Ltd.
Contact:0086 429 2075777
Address:Area B,Shipbuilding Industry Park,Beigang District,Huludao City,Liaoning prov.,China
Jiangyin Tenghua Import&Export Co.,Ltd.
Contact:+86-510-86263875
Address:Room 402-B,9 Yanling Road, Jiangyin,Jiangsu, China
Doi:10.1021/ja203917r
(2011)Doi:10.1021/jm00106a052
(1991)Doi:10.1002/chem.201101033
(2011)Doi:10.1021/jo991832m
(2000)Doi:10.1002/hlca.19900730622
(1990)Doi:10.3390/molecules24081569
(2019)