3-Aminopyridazine derivatives with atypical antidepressant, serotonergic, and dopaminergic activities

Article abstract of DOI:10.1021/jm00123a004

Minaprine [3[(β-morpholinoethyl)amino]4-methyl-6-phenylpyridazine dihydrochloride] is active in most animal models of depression and exhibits in vivo a dual dopaminomimetic and serotoninomimetic activity profile. In an attempt to dissociate these two effe