Substrate attenuation: An approach to improve antibody catalysis

DOI: 10.1016/S0040-4020(01)81784-1

Source and publish data:

Tetrahedron p. 2503 - 2506 (1991)

Update date:2022-09-26

Topics:

Authors:

Janda, Kim D.

Benkovic, Stephen J.

McLeod, Donald A.

Schloeder, Diane M.

Lerner, Richard A.

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Article abstract of DOI:10.1016/S0040-4020(01)81784-1

Antibodies raised to quinaldine phosphonamide 1a showed no ability to hydrolyze its most homologous substrates amide and ester 2 and 3, respectively. However, within this same set of antibodies some thirteen showed a great propensity to hydrolyse a struct

Full text of DOI:10.1016/S0040-4020(01)81784-1

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