Tetrahedron p. 5745 - 5760 (1988)
Update date:2022-07-30
Topics:
Matsuda, Fuyuhiko
Kawasaki, Motoji
Ohsaki, Masako
Yamada, Kaoru
Terashima, Shiro
Various structural types of nogalamycin congeners and their partial structures, which had been previously synthesized in the course of our synthetic studies on the total syntheses or were originally produced by employing the explored synthetic scheme, were subjected to in vitro cytotoxicity and in vivo antitumor activity assay against P388 murine leukemia.These studies obviously disclosed novel aspects of the structure-activity relationships of nogalamycin congeners.
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