Chemistry and Physics of Lipids p. 61 - 69 (2009)
Update date:2022-08-05
Topics:
Engel, Robert
Rizzo, JaimeLee Iolani
Rivera, Christina
Ramirez, Mariah
Huang, Mia Lace
Montenegro, Diego
Copodiferro, Craig
Behaj, Valbona
Thomas, Marie
Klaritch-vrana, Barbara
Engel, Jeanne Fabian
Herein is reported the preparation of several series of polyammonium salts that serve as cationic lipids or precursors thereof, and are structurally based on the parent diamine 1,4-diazabicyclo[2.2.2]octane (dabco). Through selective alkylation of dabco a variety of di- and tetracationic lipid species and precursors thereof have been prepared. The resultant materials are of significant interest for a variety of purposes, including serving as antimicrobial agents and antihydrophobic species, the details of which are provided in separate reports.
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Doi:10.1016/j.bmcl.2009.05.021
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