A concise synthesis of penems

DOI: 10.1016/S0040-4039(00)97622-6

Source and publish data:

Tetrahedron Letters p. 4359 - 4362 (1990)

Update date:2022-07-31

Topics:

Authors:

Barker Barker

Campbell

Jenkins Jenkins

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Article abstract of DOI:10.1016/S0040-4039(00)97622-6

A brief and efficient new synthesis of 2-substituted 6-[1(R)-hydroxyethyl]-penems is described. The key step involves reaction of an azetidin-2-one-4-disulphide with either stabilized or unstablized phosphoranes, giving ylids which cyclize with the 1-oxalimide group to give 2-substituted penems.

Full text of DOI:10.1016/S0040-4039(00)97622-6

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Product name:2-{3-[(R)-1-(tert-Butyl-dimethyl-silanyloxy)-ethyl]-2-[ethoxycarbonyl-(triphenyl-λ⁵-phosphanylidene)-methylsulfanyl]-4-oxo-azetidin-1-yl}-3-methyl-but-2-enoic acid methyl ester

Cas No:118559-57-2

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