Conjugate Addition of Nitroalkanes to an Acrylate Equivalent. Stereocontrol at C-α of the Nitro Group through Double Catalytic Activation

Article abstract of DOI:10.1021/ol901351k

Figur Presented An unprecedented highly selective direct conjugate addition of prochiral nitroalkanes (R ≠ H) to acrylate equivalents is described. The method employs a unique Lewis acid/Bronsted base/MS ternary catalytic system and affords products with