Ring-construction/stereoselective functionalization cascade: Total synthesis of pachastrissamine (jaspine B) through palladium-catalyzed bis-cyclization of bromoallenes

Article abstract of DOI:10.1021/ol901904w

Palladium(0)-catalyzed cyclization of bromoallenes bearing hydroxyl and benzamide groups as internal nucleophiles stereoselectively provides functlonallzed tetrahydrofuran. With this bis-cyclizatlon as the key step, a short total synthesis of pachastrissa