N-2-Iodobenzylcinchoninium bromide is effective for catalytic enantioselective trifluoromethylation of azomethine imines in Solkane 365mfc

Article abstract of DOI:10.1016/j.jfluchem.2012.06.008

Solkane 365mfc (1,1,1,3,3-pentafluorobutane, CF₃CH ₂CF₂CH₃) is proven to be an environmental benign alternative solvent for the catalytic enantioselective trifluoromethylation of azomethine imines 1. High chemical yields and enantioselectivities (up to 96% ee) were achieved by employing previously unknown and structurally simple cinchona alkaloid ammonium salt, N-2-iodobenzylcinchoninium bromide 3d as a catalyst.