SYNTHESE EN UNE ETAPE D'α-ALCOXYHYDRAZIDES, DE DERIVES D'α-AMINOACIDES ET D'α-HYDROXYACIDES A PARTIR DES α-HALOGENOHYDRAZIDES. ETUDE DU MECANISME DE LA REACTION.

Article abstract of DOI:10.1016/S0040-4020(01)86184-6

α-Halohydrazides react with nucleophiles under basic conditions to give α-functionalized hydrazides.We have shown that this reaction is not a direct nucleophilic substitution of the halogen but more likely proceeds through the formation of an aziridinone