Synthesis of tetrahydropyrans from propargyl alcohols and 1,1-cyclopropanediesters: A one-pot ring-opening/Conia-ene protocol

DOI: 10.1021/jo9019122

Source and publish data:

Journal of Organic Chemistry p. 8414 - 8416 (2009)

Update date:2022-08-05

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Authors:

Leduc, Andrew B.

Lebold, Terry P.

Kerr, Michael A.

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Article abstract of DOI:10.1021/jo9019122

(Chemical Equation Presented) Lewis acid catalyzed ring opening of 1,1-cyclopropanediesters by the hydroxyl group of a propargyl alcohol sets up a subsequent Conia-ene cyclization to afford substituted tetrahydropyrans in a one-pot, high-yielding procedur

Full text of DOI:10.1021/jo9019122

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