Recyclable catalytic synthesis of substituted quinolines: copper-catalyzed heterocyclization of 1-(2-aminoaryl)-2-yn-1-ols in ionic liquids

Article abstract of DOI:10.1016/j.tet.2009.08.017

A convenient and simple approach for the recyclable catalytic synthesis of substituted quinolines is presented. The method is based on CuCl₂-catalyzed heterocyclization of readily available 1-(2-aminoaryl)-2-yn-1-ols in BmimBF₄ as the solvent at 100 °C for 15-24 h. The solvent-catalyst system could be successfully recycled up to six times without significant loss of activity.