Tetrahedron Letters p. 4523 - 4526 (1999)
Update date:2022-08-02
Topics:
Beller, Matthias
Moradi, Wahed A.
Eckert, Markus
Neumann, Helfried
A new and improved variant of the palladium-catalyzed amidocarbonylation to yield N-acyl-α-amino acids is described. Using Pd/C as catalyst the products were prepared in good to excellent yields (up to 98 %). Advantages of the Pd/C-catalyst with regard to former catalyst systems are demonstrated by the preparation of N-substituted non-natural amino acids which are of current interest as structural units of peptoids.
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Doi:10.1021/bm1013662
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