SYNTHESIS OF Β-FUNCTIONALIZED α,β-DEHYDROAMINO ACID DERIVATIVES

Article abstract of DOI:10.1016/S0040-4020(01)86052-X

β-functionalized α,β-unsaturated amino acids were synthesized by an addition-elimination pathway.Reaction of methyl β-bromo-α-formylaminoacrylates ( 3a-e ), which were prepared by the condensation of methyl isocyanoacetate ( 1 ) with aldehydes followed by