Tetrahedron Letters p. 4629 - 4630 (1988)
Update date:2022-08-02
Topics:
Cameron, Donald W.
Feutrill, Geoffrey I.
Griffiths, Peter G.
Hydrogenation of daunomycin(1) and adriamycin(2) has afforded deoxygenation at position 5 with retention of the 7-glycoside.The resulting 5-deoxyanthracyclines (3), (4), (12), (13) represent a new family possessing high anticancer activity.
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