Synthesis and studies of piperidinone, the major metabolite of a new antidepressant drug S 3344

Article abstract of DOI:10.1002/jhet.5570250550

The synthesis of 1-(4-fluorobenzyl)-6-isopropyl-2-piperidinone 7a, a major metabolite of a new antidepressant S 3344, is described and then substituted with various substituents. The ¹H and ¹³C nmr provide information on their struct