Inhibition of Mammalian Folylpolyglutamate Synthetase and Human Dihydrofolate Reductase by 5,8-Dideaza Analogues of Folic Acid and Aminopterin Bearing a Terminal L-Ornithine

DOI: 10.1021/jm00127a026

Source and publish data:

Journal of Medicinal Chemistry p. 1559 - 1565 (1989)

Update date:2022-08-05

Topics:

Authors:

Patil, Shirish A.

Shane, Barry

Freisheim, James H.

Singh, Shyam K.

Hynes, John B.

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Article abstract of DOI:10.1021/jm00127a026

Six new 5,8-dideaza analogues of folic acid and aminopterin containing a terminal L-ornithine residue were prepared by using multistep synthetic sequences.Each was evaluated as an inhibitor of hog liver folylpolyglutamate synthetase and human dihydrofolat

Full text of DOI:10.1021/jm00127a026

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