Inhibition of Mammalian Folylpolyglutamate Synthetase and Human Dihydrofolate Reductase by 5,8-Dideaza Analogues of Folic Acid and Aminopterin Bearing a Terminal L-Ornithine

DOI: 10.1021/jm00127a026

Source and publish data:

Journal of Medicinal Chemistry p. 1559 - 1565 (1989)

Update date:2022-08-05

Topics:

Authors:

Patil, Shirish A.

Shane, Barry

Freisheim, James H.

Singh, Shyam K.

Hynes, John B.

Read Full Text PDF DownLoad Join now for total 90,000,000 free articles

Article abstract of DOI:10.1021/jm00127a026

Six new 5,8-dideaza analogues of folic acid and aminopterin containing a terminal L-ornithine residue were prepared by using multistep synthetic sequences.Each was evaluated as an inhibitor of hog liver folylpolyglutamate synthetase and human dihydrofolat

Full text of DOI:10.1021/jm00127a026

Products guided by the article

Product name:6-<methyl>-5-chloro-2,4-diaminoquinazoline

Cas No:120296-61-9

R&D Labs maybe for 120296-61-9

Zhejiang Genebest Pharmaceutical Co.,Ltd.

Contact:0086-571-63532866

Address:No.1 Jinboshi Rd Lishan Town Fuyang City Zhejiang Province China
Changzhou Ansciep Chemical Co.,Ltd.

Contact:+86 519 8630 5871

Address:A-710 Boan International, 8 East Guangdian Road,Wujin,Changzhou
Suzhou Jingye Medicine & Chemical Co., Ltd

Contact:+86-512-66658588

Address:No. 88, Sanlian Street, Jinfeng Road, Suzhou New District, Jiangsu Province, P. R. China
SHENYANG COMEBOARD TECHNOLOGY CO., LTD

Contact:+86-24-25724626

Address:Room2210,Tianbao International Building,No.8-1 Weigong South Street,Tiexi District,Shenyang,China
HangZhou HuaYe Chemical Technology Co.,Ltd

Contact:+86-13505815007

Address:hangzhou

Relevant to this article

Design, synthesis of novel, potent, selective, orally bioavailable adenosine A₂A receptor antagonists and their biological evaluation

Doi:10.1021/acs.jmedchem.6b01584
(2017)
Discovery of novel benzylidene-1,3-thiazolidine-2,4-diones as potent and selective inhibitors of the PIM-1, PIM-2, and PIM-3 protein kinases

Doi:10.1016/j.bmcl.2012.05.098
(2012)
Thermosensitive hydrogels composed of cyclodextrin pseudorotaxanes. Role of [3]pseudorotaxane in the gel formation

Doi:10.1039/b911667b
(2009)
A symmetry-based synthesis of the heterobicyclic core of the zaragozic acids/squalestatins

Doi:10.1002/adsc.200900295
(2009)
Antimicrobial activity of stereoisomers of butane-type lignans

Doi:10.1271/bbb.90167
(2009)
Non-heme iron oxygenases generate natural structural diversity in carbapenem antibiotics

Doi:10.1021/ja907320n
(2010)

Article Doi