Journal of Medicinal Chemistry p. 1559 - 1565 (1989)
Update date:2022-08-05
Topics:
Patil, Shirish A.
Shane, Barry
Freisheim, James H.
Singh, Shyam K.
Hynes, John B.
Six new 5,8-dideaza analogues of folic acid and aminopterin containing a terminal L-ornithine residue were prepared by using multistep synthetic sequences.Each was evaluated as an inhibitor of hog liver folylpolyglutamate synthetase and human dihydrofolat
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