NEW APPROACHES TO THE ASYMMETRIC SYNTHESIS OF NON-PROTEINOGENIC α-AMINO ACIDS AND DIPEPTIDES THROUGH CHIRAL β-LACTAM INTERMEDIATES

Article abstract of DOI:10.1016/S0040-4020(01)86038-5

Novel and effective routes to optically pute aromatic α-amino acids, α-methyl-α-amino acids and their derivatives including dipeptides are developed via homochiral β-lactams which are obtained through asymmetric <2+2> cycloadditions of ketenes to imines.