Antagonistes calciques. I. Remplacement du groupe dimethoxy-3,4- phenylethyle du verapamil

Article abstract of DOI:10.1016/0223-5234(90)90119-N

In the verapamil structure, the 3,4-dimethoxy phenylethyl group has been replaced by several moieties belonging to α- and β-blockers or other classes of calcium channel blockers.The best derivatives, as calcium blockers, were prepared with β-blocker fragments like aryloxypropanolamines (AOPA) with an ortho substituent on the aromatic ring.