European Journal of Medicinal Chemistry p. 351 - 359 (1990)
Update date:2022-08-04
Topics:
Laguerre, M.
Boyer, C.
Carpy, A.
Panconi, E.
Cognic, F.
Vaugien, B.
In the verapamil structure, the 3,4-dimethoxy phenylethyl group has been replaced by several moieties belonging to α- and β-blockers or other classes of calcium channel blockers.The best derivatives, as calcium blockers, were prepared with β-blocker fragments like aryloxypropanolamines (AOPA) with an ortho substituent on the aromatic ring.
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