Transition metal-free direct amination of benzoxazoles using formamides as nitrogen sources

Article abstract of DOI:10.1016/j.tetlet.2014.02.070

A transition metal-free method for the direct amination of benzoxazoles using formamides as nitrogen sources is reported, which was mediated by an inexpensive and environmentally friendly tetrabutylammonium iodide/tert-butyl hydroperoxide system and gave the 2-aminobenzoxazole derivatives with moderate to good yields.