Tetrahedron Letters p. 4513 - 4516 (1988)
Update date:2022-07-30
Topics:
Wehmeyer, Richard M.
Rieke, Reuben D
Highly reactive copper solutions have been prepared by the lithium naphtalide reduction of copper(I) iodide/triphenyl-phosphine complex.These copper solutions react rapidly with functionalized alkyl halides to give organocopper reagents wich have been effectively trapped with acid chlorides giving functionalized ketones in good yields.Ester, nitrile, chloride, remote epoxide, and, to some degree, ketone groups can be tolerated by this approach.
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