Journal of Medicinal Chemistry p. 9323 - 9342 (2014)
Update date:2022-08-15
Topics:
Menet, Christel J.
Fletcher, Stephen R.
Van Lommen, Guy
Geney, Raphael
Blanc, Javier
Smits, Koen
Jouannigot, Nolwenn
Deprez, Pierre
Van Der Aar, Ellen M.
Clement-Lacroix, Philippe
Lepescheux, Liên
Galien, René
Vayssiere, Béatrice
Nelles, Luc
Christophe, Thierry
Brys, Reginald
Uhring, Muriel
Ciesielski, Fabrice
Van Rompaey, Luc
Janus kinases (JAK1, JAK2, JAK3, and TYK2) are involved in the signaling of multiple cytokines important in cellular function. Blockade of the JAK-STAT pathway with a small molecule has been shown to provide therapeutic immunomodulation. Having identified
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