Transition Metal-Catalyzed, Chlorine-Transfer Radical Cyclizations of 2-(3-Alken-1-oxy)-2-chloroacetates. Formal Total Synthesis of Avenaciolide and Isoavenaciolide

DOI: 10.1021/jo00087a011

Source and publish data:

Journal of Organic Chemistry p. 1993 - 2003 (1994)

Update date:2022-08-04

Topics:

Authors:

Udding, Jan H.

Tuijp, Kees (C.) J. M.

Zanden, Marco N. A. van

Hiemstra, Henk

Speckamp, W. Nico

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Article abstract of DOI:10.1021/jo00087a011

A novel method for the synthesis of functionalized tetrahydrofurans is described.This method involves the treatment of 2-(3-alken-1-oxy)-2-chloroacetates 1 with a catalytic amount of Cu(bpy)Cl in refluxing 1,2-dichloroethane to give good yields of 3-(1-ch

Full text of DOI:10.1021/jo00087a011

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