Synthesis of the "Tricarbonyl" Region of FK-506 through an Amidophosphorane

DOI: 10.1021/jo00273a004

Source and publish data:

Journal of Organic Chemistry p. 2785 - 2786 (1989)

Update date:2022-08-04

Topics:

Authors:

Wasserman, Harry H.

Rotello, Vincent M.

Williams, David R.

Benbow, John W.

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Article abstract of DOI:10.1021/jo00273a004

A protected C₁-C₁₅ segment of FK-506 has been prepared by coupling of the acid chloride 4 with the ylide amide 3 derived from (-)-pipecolinic acid.A method for the conversion of this unit to the vicinal diketo amide 6 and to the corresponding hemiketals 7 and 8 is outlined.

Full text of DOI:10.1021/jo00273a004

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